Pyrrole-2-carboxylic acid

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Pyrrole-2-carboxylic acid was first identified as a degradation product of sialic acids then as a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase.

Pyrrole-2-carboxylic acid was first identified as a degradation product of sialic acids then as a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. The latter relationship results from the lability of the direct oxidation product A'-pyrroline-4-hydroxy-2-carboxylic acid which loses water spontaneously to form the pyrrole. A similar reaction is catalyzed by the more specific allohydroxy-D-proline oxidase of Pseudomonas. In whole animal observations pyrrole-2-carboxylate (PCA) ' was identified in rat or human urine after administration of the D-isomers of hydroxyproline a finding ascribable to the action of D-amino acid oxidase. Urinary excretion of N-(pyrrole-2-carboxyl) glycine has been reported in a 5-year-old affected with type II hyperprolinemia; The child has mild developmental delay recurrent seizures of the grand mal type and EEG alterations.

2-Pyrrolecarboxylic acid;Minaline

Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

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634-97-9

111.1

C5H5NO2

>98% (HPLC)

DMSO:10uM;Methanol: Soluble

OC(=O)c1ccc[nH]1

——

(-20℃)

With Ice Pack

≥ 2 years